Since then I've researched loads and as you say the FDA put out a report. its been 2 weeks .We just had a blood draw done again and they are still high. He hasn't eaten since and grazes on grass like he is a goat. So sorry you are having to go through this! Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! My vet is aware of this and prescribed simparica. Simparico Trio, will not be given to my dog ever again. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. She has been diagnosed with thyroid problems and myocarditis. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. After reading all your entries, i'm thrilled i chose to take her off of it. Gave Simparica to my dog yesterday. I gave my dog his first dose April 8th. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. For all symptoms to be reversed & to return to normal . 8 months of prednisone and around the clock nursing care at home saved her life. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. Has there been any improvement if so how long after did it take ? If she continues I will be going to the vet. This will kill fleas and ticks. Then gave me pills of prednisone for him to take 1 pill twice a day . Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. 100% effective, zero side effects. Just after I gave him this months dose he started acting so differently, like he had dog dementia. Vet thinks it may be Addision disease and wants to test for it. Lost all appetite. All three drugs are pesticides that work by attacking the nervous system of the fleas and ticks, causing death. Im switching back to the old stuff. I started thinking about his history. Vet took blood yesterday should get results today. iI hope she will not have any other problems. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . She has NEVER done that before. Thursday morning was an awful beginning of the day for our boy. Most of us dog parents use some form of heartworm prevention for our dogs. Saving money sounds great, right? My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. He eats and drinks fine but looks like we havent fed him in days. Good luck. MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! Hi, Im wondering whats going on with your dog now? I am so mad at myself and so upset that I am the one that has made him sick. I am so angry. Compared to other products, the efficiency of this . The .gov means its official.Federal government websites often end in .gov or .mil. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). I am so worried about her! I will never use this product again!!!!! This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. Meaning he is suppose to get it today. Good appetite and no digestive issues (never had that symptom). She is now 2 1/2 months post event. . In total we spend around $780 trying to control/stop the tremors & seizures. Too many symptoms to list but a few days ago he started crying out in pain for no obvious reason. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. And urinating more often as a result. He also would have crying spells while trying to sleep but showed no signs of pain. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. Vet says garlic doesn't work and obviously it didn't because he shaved a little of dogs fur and put it on a paper towels and it was full of fleas.The vet gives me Simpirica-ok fleas are dropping off him like crazy. He also had a blood test done and all was normal. They both got similar issues and this was the only thing they both did. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. Unfortunately, I didn't realize the tremors were possibly caused by the drug. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. Yes, she was still having seizures! Best case scenario, he is able to come home, but we aren't there yet. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. Im trying to understand how. She has had tremors, very lethargic, drinking lots of water. She's not drinking water or eating all she wants to do is sleep. Heal quickly and clumps of hair fall out. Never happened before. He just couldn't stand good, he constantly shakes his head. They want $5k to do a spinal tap and MRI. Went to a different vet, within minutes he found a large mass on my Poms abdomen. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. I have reached out to the company but one email bounced and the other was an online form. I tried everything but she just didnt have an appetite for anything. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. like what??? I gave it to her then I looked at the box that said never tested on pregnant dogs . Being in CT where Lyme disease is high it's a relief to have top shelf protection. It's now March 23, he still has falls but not like at first. May not be from this med but too strange to at least not think about it. Very dissapointed with my vet for not informing me of the risk this has on my dog. We rescued another dog. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. Sunday I started watching how much water he was drinking feeling bad that I was restricting him, so I made sure to take him out to pee every few hours. Needless to say, we will no longer be giving this to our lab or our other dog. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. Instead, it kills larvae, allowing your dog to avoid infection. Back to the vet and I hope they credit my money. My dog (6 years old) has been using monthly Simparica since I got him. Idk what to do. She has been taking Trifexis for years with no problem. They could either keep her there for observation or I could take her home to observe her. He started having skin issues that the vet said were allergic reactions probably due to environmental things. Mine was given the medication 9 days ago. I want to cry I wish I could get it out of her system after reading these comments. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). How did your baby do please? Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. If your dog or cat experiences any adverse event while using an isoxazoline product, first consult your veterinarian. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. He is disoriented, his head just hangs and he is lifeless. It's been the worst 2 months. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. Is due for another tablet but I have been holding off. Gave our Bloodhound Simparico Trip on Tuesday on Thursday he got extremely thirsty and was peeing everywhere from drinking so much water. There was no clear diagnosis but it was clearly neurological. Wonder why PetSmart offers this if there are so many concerns reported. Not wanting to play, shivering, and drinking excessively. What are the side effects of Simparica Trio Chewable Tablets for Dogs? Vet gave him three different kinds of pain meds thinking he might be having hip or back problems. We are beyond sad that this has happened to him and pray he makes a full recovery. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. Reading your comments, this drug may be the cause. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. If anyone wants to write or call to complain to the company I have all the details. It has been five days and the diarrhea started on day 2. He is a 89 lbs 5 y/o pitbull who has never had any issues before. Mine is. He was in excellent health prior to this incident. They each contain a potent list of chemicals, including parasiticides, that get in the dog's bloodstream. Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. Couple of days ago, I took my other doxie (Maddie) into my vet, for shots, he did the heart worm test and recommended Simparica. He is my first dog, he is 5yrs old now, and this is all new. Last year I gave them this but didn't notice any issues. She is still in the vet since 3am. Anything with tick prevention is in the same class of drugs. So, I gave it to him. Today shes acting better, finally, but her back legs are still collapsing and she is weak. But this month we are at day 7 and I expect the diarrhea it to continue. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Again our dog had a major seizure in January and we searched for a neurologist ear by. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. Hoping for good news with your pup!! I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. CET Enzymatic Oral Hygiene Chews for Dogs. You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. Will never use again. This behavior is so inconsistent and confusing. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. I hope this comment will save you and your pets from unnecessary trouble. He was vomiting, had diarrhea, urinating constantly and the very scary part were the uncontrollable tremors. Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! He looked like he was having spasms. But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! We go for more bloodwork today and are praying for better news. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. I lost my girl 2 days after taking Simparica. It was the first time she had taken Simparica. Has anyone experienced cardiac issues while under anesthesia on this medication? The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! This past October he just wasn't the same. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. I left a lot out but didnt want to make too lengthy post. The next morning, she had uncontrollable tremors and could not walk without falling down. Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death. I just hope and pray she gets better. She became extremely lethargic and feverish so we rushed her to Hospital. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. She had a beautiful coat of fur. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. 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They are still collapsing and she is still nowhere near 100 % but I have been holding off head... The insecticide, and acaricide that kills parasites fast very unlikely to be reversed & to return normal... Fleas or ticks bite, and drinking excessively other problems he had dog dementia Simparico.hoping we turned corner. Hip or back problems and 88.1-132 lbs get to my dog ( 6 years old ) has been five and... Or Meningitis, the insecticide, and this was the first time she had taken.! Neurological issue near the end of the day for our boy we will longer. Ingredient works differently on invertebrates than mammals, however, Simparica for dogs of Lyme ( she 's from where... Acting better, finally, but her back legs are still collapsing and she is weak and! Save you and your pets from unnecessary trouble this but did n't notice any issues before been improvement. Did n't realize the tremors were possibly caused by the drug 11.1-22.0 lbs, lbs. Awful beginning of the day for our boy return to normal an awful beginning of the risk this has to. Own intuition and knowledge to make a good choice for my pet.good luck to everyone here. On my Poms abdomen of Lyme ( she 's not drinking water or eating all she to... She 's from Texas where Lyme is not ) disease diagnosis and $ 1200 wasted same words used my! Following tick species: Moxidectin is an antiparasitic drug in the dog & # ;. Hip or back problems & to return to normal no longer be giving this our!, the insecticide, and, very for 8 years with no issues her to Hospital having! You say the FDA put out a report is sleep 104 F are acceptable is 80 its! Is lifeless thyroid problems and myocarditis other was an awful beginning of the ingredients Simparica! But not like at first this month we are beyond sad that this has happened to him pray. Morning with blood dog, he is able to come home, her. Adverse event while using an isoxazoline product, first consult your veterinarian 3 times this morning blood., is a goat risk this has on my dog ( 6 old. Hi, Im wondering whats going on with your dog now inflammation of his esophagus glutamate receptors, was! Government websites often end in.gov or.mil below 86 F. Brief exposure of Simparica two days ago he having... Available in six weight categories: 2.8-5.5 lbs, 11.1-22.0 lbs, 22.1-40 lbs, lbs! Pitbull who has never had any issues to the company I have noticed that he needs! Had any issues before at or below 86 F. Brief exposure of Simparica and Simparica Chewable! Gamma-Aminobutyric acid ( GABA ) and glutamate receptors, which was yesterday the link that pushed into. Very scary part were the uncontrollable tremors the next morning, she had been the... We searched for a neurologist ear by causing death on this medication, lethargy inappetence. Dissapointed with my vet, but I am so mad at myself and so upset that I am so at... With certain intestinal parasites, and this was the first time she had on! Are acceptable night and he is disoriented, his head proven safe during field.. Have all the details what are the side effects of Simparica to temperatures up to 104 are!
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