Association between mRNA vaccination and COVID-19 hospitalization and disease severity. 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. Received: 25 November 2022; Accepted: 20 February 2023;Published: 03 March 2023. Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Costa Clemens SA, Weckx L, Clemens R, Almeida Mendes AV, Ramos Souza A, Silveira MBV, et al. We dont know about asymptomatic carriersthat is, Type O could still pass along the virus to other people unknowingly just as much as Type A could. But let's back up first. And clotting issuesincluding strokes, kidney failure, and pulmonary embolismscome up a lot with Covid infections. Finsterer J. To our knowledge, this study is the first to report that a heterologous Chinese COVID-19 inactivated vaccine administration schedule induced humoral and cellular immune responses in humans and that it was associated with an acceptable and manageable reactogenicity profile 240 days after vaccination. We found that participants with a longer interval between vaccination doses (4056 days) had higher levels of neutralizing antibodies than those with a shorter interval (2140 days). } else { We may earn commission from links on this page, but we only recommend products we back. We only observed a trend of decreasing neutralizing antibodies after vaccination over time. Keywords: 2022 Aug 15;369:577901. doi: 10.1016/j.jneuroim.2022.577901. The https:// ensures that you are connecting to the People with Type O blood might be slightly more protected from the virus, and people with Type A slightly more vulnerable. 2021;144(1):109110. Lower antibody concentrations were correlated with older age, longer duration after vaccination, non-health care workers, mixed-manufacturer vaccinations, and intervals of less than 40 days between two doses of vaccination, whereas lower IFN- levels and B-lymphocyte counts were associated with older age, blood type A, and non-health care workers. The discovery of Type Os protective effect is crucial to building an understanding of how the virus works. 30. "We don't know why that is, how long these symptoms will last or if there are effective ways to treat them. All authors contributed to the article and approved the submitted version. Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report. Therefore, we could not determine the level of neutralizing antibodies against viruses that cause breakthrough infection or severe infection. Finally, individuals with certain occupations, including workers, especially older individuals and men, had low levels of antibodies and had weakened cellular immune responses following the second dose compared to their counterparts, suggesting that a longer gap between vaccine doses, which is a strategy in effect in some countries, should be re-evaluated, especially for more susceptible populations. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. The researchers at St. Michael's Hospital in Toronto, Canada, examined the test results of 225,556 Canadians who had been tested for COVID-19 between Jan. 15 and Jun. These fun facts about everything from the cosmos to the inner workings of your body will blow your mind. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). And guess what: People with Type A blood have higher levels of VWF naturally than people with type O blood, Dr. Udden points out. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. This result indicates that by changing the interval between vaccinations with the inactivated vaccine from the current 38 weeks to 610 weeks (12), vaccinated people can produce higher levels of neutralizing antibody. Factors that influence humoral and cellular immune responses were defined within 240 days in individuals vaccinated with an inactivated Chinese vaccine. The levels of IFN- and CD4+ T-lymphocytes were not altered in the participants for 240 days after vaccination, whereas the levels of neutralizing antibodies, B-lymphocytes, and IL-6 decreased with increasing time after vaccination. doi:10.1001/jama.2021.19499, 11. This study was a multicenter, longitudinal, prospective, observational study conducted in two hospitals (Henan Provincial Peoples Hospital and Zhengzhou Municipal Chinese Medicine Hospital) and one institution (Henan Electric Power Survey and Design Institute) in central China. doi:10.1016/S1473-3099(21)00479-5, 17. COVID19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey. Neutralizing antibodies, interferon-gamma (IFN-), interleukin (IL)-6, CD4+ T-lymphocyte, and B-lymphocyte counts were evaluated in serum samples after stimulation with 2 g/mL SARS-CoV-2 spike protein for 16h at follow-up intervals of 2 months. Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. Experts say more . Domingo JL. doi:10.2196/26089, 24. A review of neurological side effects of COVID-19 vaccination. Side effects may even feel like flu and might affect your ability to do daily activities,. No. Furthermore, based on the study of Lusting etal. To date, coronavirus disease 2019 (COVID-19), a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 600 million people worldwide and killed over 6 million people (1, 2). Unfortunately, this is a much more rare blood type. xhr.setRequestHeader('Content-Type', 'text/plain;charset=UTF-8'); It's normal to experience side effects after the vaccine. Epub 2021 May 25. *Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all Read on to find out if you're safe, and for more risky behavior to be aware of, know that It Only Takes This Long to Get COVID in a Room With Someone Who Has It. This may be due to the increased exposure of medical staff to patients with COVID-19 compared to people in other occupations. According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { Therefore, we designed a multicenter, longitudinal, observational study to evaluate the immunogenicity and reactogenicity of a second dose of inactivated vaccine among those who received the two vaccines from different manufacturers. They looked at patients from March 3 to Nov. 2, 2020 who were tested for SARS-CoV-2 and had a recorded blood type, comparing positive versus negative tests, hospitalized versus non-hospitalized patients and ICU versus non-ICU patients. These include anaphylaxis, a severe reaction . Possible side effects: Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. The most common side effect of the vaccine is temporary soreness and swelling at the injection site. The retailer is being called out over its strict security measures. (EG) Kinetics of interferon (IL)-6 levels according to (E) age, (F) vaccine manufacturer, (G) occupation and (H) interval between doses of vaccination. "It's pretty clear that Type O is protective to some degree. Figure2 Quantitation of antibodies on days 1240 following administration of the Chinese inactivated vaccine. A previous study in the journal Blood Advances from 2020 also affirmed this research, adding that people with Type O blood seem to be more protected from Covid. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. official website and that any information you provide is encrypted Clinics. First there is a reaction in the arm where you are injected - think swelling and soreness - as the immune system swings into gear. Diarrhea. What Your Blood Type Has to Do With Getting Covid, This Coffee Shop Provides Free Therapy for Men, Your Privacy Choices: Opt Out of Sale/Targeted Ads. 2021;8(2021):3619131. doi:10.1155/2021/3619131 Even DNA testing company 23andMe tapped their customers and found that among 750,000 people who were diagnosed and hospitalized for Covid (this was prior to vaccines), those with type O were more protected. It may affect your immune systems strength or your inflammatory response to the infection. There were no differences in the positive rate of neutralizing antibodies between the groups throughout the observation period (p = 0.891; Figure2A). Post SARSCoV2 vaccination GuillainBarre syndrome in 19 patients. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. Furthermore, this study was the first to explore the association between the blood type of participants and humoral and cellular immune responses within 240 days after the administration of a Chinese inactivated vaccine. At 240 days after vaccination, the GMC of neutralizing antibodies in the mixed-manufacturer vaccination group decreased to 8.5 IU/mL, which was less than the decrease detected in the same-manufacturer vaccination group (20.5 IU/mL) (p < 0.001). Research in other countries has shown that the antibody titer of individuals vaccinated with a different type of vaccine 28 days after the first vaccination was higher than that of individuals vaccinated with a vaccine from the same manufacturer for both doses, without an increase in adverse reactions (14). ABO blood typing was performed using a test-tube method according to the manufacturers protocol (Chengdu Xiehe Ltd., Co., Chengdu, China). The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). Desmecht S, Tashkeev A, El MM, Marechal N, Pere H, Tokunaga Y, et al. Front. Opens in a new tab or window, Visit us on TikTok. 2023 Feb 25;28(1):102. doi: 10.1186/s40001-023-00992-0. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. The log2-transformed level of neutralizing antibodies was used as the independent variable. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. doi:10.1038/s41422-021-00590-x, 23. Following vaccination, the participating medical staff of Henan Provincial Peoples Hospital and Zhengzhou Municipal Traditional Medicine Hospital, and workers of the Henan Electric Power Exploration Company in central China were followed up monthly for 8 months between June 19, 2021, and April 30, 2022. as it pertains to all aspects of your daily life. J Neuroimmunol. doi:10.1002/jmv.27825, 10. You'll always want to stay at your vaccination site for at least 15 minutes after you get the shot (30 minutes if you've had a severe allergic reaction before). According to the manufacturers instructions, values > 100 IU/mL were considered as 100 IU/mL. You will see significant upgrades in-store and online this year. doi:10.12659/MSM.938532, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Along with its needed effects, sars-cov-2 (covid-19) mrna-1273 vaccine (the active ingredient contained in Moderna COVID-19 Vaccine) may cause some unwanted effects. Additionally, "Rh had a lower [adjusted relative risk] of severe COVID-19 illness or death.". The signs are trouble breathing, swelling of the face and throat, rash, and low blood pressure. 1:38 Syncope following injection 2:36 Primarily headaches 3:37 Clotting disorder after vaccination 4:37 Any neurological events 4:50 Dexamethasone and surgical site infection 5:51 Also had people. SARS-CoV-2 and adverse reactions to SARS-CoV-2 vaccinations show a tropism for neuronal structures and tissues. Participants with a clinically notable acute illness or a body temperature of at least 38C within 24h before receiving the planned dose of the study vaccine, clinical manifestations compatible with those of COVID-19, and any condition that contraindicates or discourages the administration of an inactivated vaccine, including pregnancy, were excluded (15). Table5 Factors associated with B-lymphocyte count after the administration of the inactivated Chinese COVID-19 vaccine. Federal government websites often end in .gov or .mil. Safety of COVID-19 Vaccines Some people have no side effects. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Adverse reactions were mild or moderate and self-limited, with no serious events reported. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. doi:10.1016/j.vaccine.2020.12.083, 6. Hearst Magazine Media, Inc. All Rights Reserved. Cell Res (2022) 32:1036. Lau YL, Fan Leung T, Sirvan Cetin B, Cagri Dinleyici E, Huang LM, Halperin SA, et al. Acceptance of COVID-19 booster vaccination based on the protection motivation theory: A cross-sectional study in China. Comment on "SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fiber neuropathy by J. Finsterer. Most participants rapidly developed neutralizing antibodies after two doses of the Chinese COVID-19 inactivated vaccine administered 3 weeks apart. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). Ackah BBB, Woo M, Stallwood L, Fazal ZA, Okpani A, Ukah UV, et al. There were no changes in IFN- levels and CD4 T+ lymphocyte count on days 1 to 240 (B = 0.2, 95% CI 0.03 to 0.4, p = 0.09 and B = 0.004, 95% CI 0.005 to 0.003, p = 0.105; Tables3, 4) in participants stimulated with the SARS-CoV-2 S antigen. Unexplained deaths. Neutralizing antibody levels usually increase after the second administration of mixed vaccines (22, 23). We know the Covid virus damages the lining of your blood vessels. The new study's co-author, Joel Ray, MD, of St. Michael's Hospital, suggested that people with these more resistant blood types may have already developed antibodies that can recognize certain aspects of the novel coronavirus and are therefore better prepared to fight it off. From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. Immune responses to the heterologous vaccination schedule were within the range of those reported using homologous schedules. In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G). Unauthorized use of these marks is strictly prohibited. The two tubes with the EDTA anticoagulant were used to determine lymphocyte subsets with or without antigen-stimulated SARS-CoV-2 spike peptides, and the two tubes without the EDTA anticoagulant were used to determine neutralizing antibodies against SARS-CoV-2 and cytokines with or without antigen-stimulated SARS-CoV-2 spike peptides. In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. INTRODUCTION The goal of this study was to evaluate the side effects of application of the Pfizer BioNTech vaccine on the workers at a Mexican hospital. Zhonghua Jie He He Hu Xi Za Zhi (2021) 44:49296. The platelets, which normally promote wound healing, end up clumping and causing blood. The Centers for Disease Control and Prevention on Friday published new data listing the most common side effects Americans reported after receiving shots of Pfizer 's or Moderna 's Covid-19 vaccines. doi:10.6061/clinics/2021/e3286 doi:10.3760/cma.j.cn112147-20200928-01013, 5. To address this issue, in 1991, a group of scientists in Minnesotaat the Department of Veterans Affairs and the . Table3 Factors associated with the levels of interferon-gamma after the administration of the Chinese inactivated COVID-19 vaccine. doi:10.1016/S2213-2600(22)00087-X, 8. Bookshelf There's no known connection between blood types and side effects from COVID-19 vaccines. Kaulen LD, Doubrovinskaia S, Mooshage C, Jordan B, Purrucker J, Haubner C, Seliger C, Lorenz HM, Nagel S, Wildemann B, Bendszus M, Wick W, Schnenberger S. Eur J Neurol. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The site is secure. We identified age as a contributing factor; with increasing age, the antibody concentration generated was decreased, and the rate of decrease in the neutralizing antibody concentration was rapid (age 3150 years vs. age 1830 years, B = 0.31, 95% CI 0.5 to 0.1; p = 0.009; Table2; Figure2C). Li G, Cappuccini F, Marchevsky NG, Aley PK, Aley R, Anslow R, et al. -. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-s-primed participants (CombiVacS): A multicentre, open-label, randomised, controlled, phase 2 trial. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The clots can clog up important . It varies from person to person, but how dramatic the initial response is does not necessarily relate to the long-term response. Once a vaccine goes into your arm, your blood flow increases and immune cells rush to the scene. Are the Vaccines Safe? The studies involving human participants were reviewed and approved by the ethics committee of Henan Provincial Peoples Hospital. Rachael Schultz is a freelance writer who focuses primarily on why our bodies and brains work the way they do, and how we can optimize both (without losing our sanity). Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: A sentinel surveillance study. Based on their age, we divided the participants into three groups, namely, 1830, 3150, and >50 years old. "There are two possibilities: You're Type O so you might not contract the virus because it has no landing stripthere's nothing to attach to," Dr. Udden explains. IntroductionIn China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or the same manufacturer remain unclear. var payload = 'v=1&tid=UA-72659260-1&cid=2f9e6afa-a882-42d6-9b30-4ccf7f6b30d2&t=event&ec=clone&ea=hostname&el=domain&aip=1&ds=web&z=6208911184915564277'.replace( 'domain', location.hostname ); Women and younger adults tend to have more side effects than men or older adults do. "Reassuring the public that everything is being done . Therefore, we were able to collect data of a few individuals who had received mixed vaccinations at the time. Blood type is not associated with a severe worsening of symptoms in people who have tested positive for COVID-19, report Harvard Medical School researchers based at Massachusetts General Hospital. But VWF also . Our team of editors strives to be objective, unbiased, and honest. Si vous souhaitez personnaliser vos choix, cliquez sur Grer les paramtres de confidentialit. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19,. For a March study out of the Southern University of Science and Technology in Shenzhen, China, scientists tracked the blood types of nearly 2,200 COVID-19 patients in Chinese hospitals, along with those of about 27,000 individuals who didn't have COVID-19 in the same areas. In the future, we will include more participants after administering booster vaccines and conduct pseudo-virus neutralization tests to address these limitations. Therefore, we speculate that the concentration of neutralizing antibodies may be increased more rapidly after the third or fourth dose of booster. While Anderson and colleagues noted their sample was mostly white, with a minority contribution from other ethnicities, they added their results were similar when restricted to white race alone. Healthcare professionals, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should stay vigilant to recognize them early and treat them adequately. Other neurological side effects occur in a much lower frequency. doi:10.1080/14760584.2021.1971523, 13. This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. If a patient was O-negative, they were particularly protected from the novel coronavirus, the authors noted. var xhr = new XMLHttpRequest(); ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. Associations between blood type and COVID-19 infection, intubation, and death. YY and JX designed the study, analyzed the data, and wrote the manuscript. doi:10.1111/ane.13451 The side effects mean your body is working hard to build the antibodies and cells it will need to fight the virus, if or when you are exposed to it. It is suggested that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. Most side effects are mild and normally last only a day or two. 2021;30(12):721146. doi:10.3389/fneur.2021.721146 Jiangsu Provincial Center for Disease Control And Prevention, China. The population required to be vaccinated included children aged 311 years, adolescents aged 1217 years, and adults. A linear regression analysis using a mixed-effect model showed that age, vaccination mode, occupation, interval between doses of vaccination, and vaccination duration were factors significantly associated with the levels of neutralizing antibodies (Tables13; Tables S1S7). Just because youre Type O doesnt mean youre in the clear. doi:10.1093/nsr/nwab193, 14. Results: Most participants [582/595; 146 male participants, 449 female participants; mean age 35 (2650 years)] rapidly developed neutralizing antibodies after two doses of the vaccine administered 3-weeks apart. Because these detected records included missing data for neutralizing antibodies and cellular immune responses, we used mixed linear models that can handle unequal numbers of repeated observations for individuals when there were random missing data. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. Front Immunol (2022) 13:863554. doi:10.3389/fimmu.2022.863554, 25. doi:10.1016/j.vaccine.2022.02.065, 16. 38 Articles, This article is part of the Research Topic, https://doi.org/10.3389/fimmu.2023.1107866, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, Creative Commons Attribution License (CC BY). Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong MKC, et al. Opens in a new tab or window, Visit us on LinkedIn. Opens in a new tab or window, Visit us on Facebook. Boosting vaccination is considered important, as antibodies and cellular immune responses were reduced in susceptible populations. doi:10.1056/NEJMoa2027187, Keywords: cellular immune response, COVID-19, inactive vaccine, kinetics, neutralizing antibody, Citation: Yuan Y, Xu J, Ma B, Chen G, Wang Z, Wang S, Jing N, Zhang J, Wang B, Yan W, Zhang Q, Zhao Q and Li Y (2023) Characteristics of humoral and cellular responses to coronavirus disease 2019 (COVID-19) inactivated vaccine in central China: A prospective, multicenter, longitudinal study. Also, if possible, get some rest. Shutterstock The researchers at St. Michael's Hospital in Toronto, Canada, examined the test results of 225,556 Canadians who had been tested for COVID-19 between Jan. 15 and Jun. On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group . Up to 10 percent of people who have COVID experience side effects" such as difficulty thinking, pain, tiredness, loss of taste and depression. Researchers in China first shared this idea in March 2020, and the findings were echoed by a paper out of Columbia University a month later. if( navigator.sendBeacon ) { Brand of vaccine administered (Moderna or Pfizer-BioNTech) and the change in average blood glucose, peak blood glucose, and percentage of time spent in normal range as well as above average range of blood glucose level following vaccine administration will be assessed. 30. Treatment of these side effects is not at variance from similar conditions due to other causes.
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